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Clinical papers

Our vision at MSD Animal Health is The Science of Healthier Animals, and Bravecto is a remarkable result of that vision. This flea and tick treatment for dogs achieves the combination of highly potent insecticidal efficacy and persistent activity with a strong safety profile.

We are very proud to bring to you the following peer-reviewed publications, recognizing that these papers present just a fraction of the tremendous effort that went into developing and obtaining regulatory approval for Bravecto (fluralaner).

A randomized, blinded, controlled and multi-centered field study comparing the efficacy and safety of Bravecto™ (fluralaner) against Frontline™ (fipronil) in flea- and tick-infested dogs

A randomized, blinded, controlled USA field study to assess the use of fluralaner tablets in controlling canine flea infestations

Fluralaner, a novel isoxazoline, prevents flea (Ctenocephalides felis) reproduction in vitro and in a simulated home environment

Insecticide_acaricide resistance in fleas and ticks infesting dogs and cats

Onset of activity of fluralaner (BRAVECTO™) against

Pharmacokinetics of fluralaner in dogs following a single oral or intravenous administration

Safety of concurrent treatment of dogs with fluralaner (Bravecto™) and milbemycin oxime – praziquantel

Safety of fluralaner chewable tablets (Bravecto™), a novel systemic antiparasitic drug, in dogs after oral administration

Safety of fluralaner, a novel systemic antiparasitic drug, in MDR1(−_−) Collies after oral administration

Safety of the concurrent treatment of dogs with Bravecto™ (fluralaner) and Scalibor™ protectorband (deltamethrin)

The effect of food on the pharmacokinetics of oral fluralaner in dogs

The speed of kill of fluraticks on dogslaner (Bravecto™) against Ixodes ricinus ticks on dog

A quantitative evaluation of the extent of fluralaner uptake by ticks (Ixodes ricinus, Ixodes scapularis) in fluralaner (Bravecto™) treated vs. untreated dogs using the parameters tick weight and coxal index

Prevention of transmission of Babesia canis by Dermacentor reticulatus ticks to dogs treated orally with fluralaner chewable tablets (Bravecto™)

Efficacy of orally administered fluralaner (Bravecto™) or topically applied imidacloprid/moxidectin (Advocate®) against generalized demodicosis in dogs

A randomized controlled trial of the efficacy of orally administered fluralaner (Bravecto™) against induced Ixodes holocyclus (Australian paralysis tick) infestations on dogs

Efficacy of fluralaner flavored chews (Bravecto) administered to dogs against the adult cat flea,Ctenocephalides felis felis and egg production

Plasma pharmacokinetic profile of fluralaner (Bravecto™) and ivermectin following concurrent administration to dogs

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